The project I'm currently working on has a large codebase and it takes a while with precompilation and everything if I press F5 to start the project every time. I therefore started to attach and detach the debugger manually every time I needed to debug. This saves me tons of time since I don't have to log in and out of the application and find the place I need to debug every time something has to be debugged. A former coworker(http://www.labraaten.com/) also made this nice little macro to attach to w3wp.exe(aspnet_wp.exe in XP) automatically. Saves me even more time.

Imports System
Imports EnvDTE
Imports EnvDTE80
Imports System.Diagnostics
Public Module Module1
    Public Sub Attach_ASPNET_WP()
        Attach("w3wp.exe")
        Attach("iexplore.exe")
    End Sub

    Public Sub Attach(ByVal processName As String)
        For Each process As EnvDTE.Process In DTE.Debugger.LocalProcesses
            If process.Name.IndexOf(processName) <> -1 Then
                process.Attach()
            End If
        Next
    End Sub
End Module

I have added this macro as a shortcut that triggers every time I hit ALT-I. This can be set by pressing tools, Options, keyboard, locating your macro and add the shortcut.